From Bottleneck to Breakthrough: Developing a Sustainable and Scalable Manufacturing Process for a Complex ADC Drug-Linker
The Merck team demonstrated the impact of applying green chemistry principles in the manufacturing process of the linker for the antibody-drug conjugate (ADC) Sacituzumab tirumotecan (MK-2870).
Recombinant DNA technology and chimeric protein expression for sustainable production of therapeutic peptides by microbial fermentation
Olon S.p.A. developed a flexible manufacturing platform for the synthesis of peptide therapeutics that reduces solvent and toxic material usage, as well as minimizing excess building blocks by using no protecting groups.
A Sustainably-Designed Manufacturing Process to Adavelt™ Active from Renewable Feedstocks
The Corteva team demonstrated the design of an efficient manufacturing process for Adavelt™ active, with sustainability as a core focus.
Walk-Up Automated Reaction Profiling (WARP) System: A Tool for Reaction Monitoring Designed for Discovery Chemists
Pfizer received this innaugral award for thier WARP system emphasizes waste reduction and minimizing exposure to hazardous substances.
Algorithmic Process Optimization (APO) for Pharmaceutical Development
The Merck and Sunthetics team developed and demonstrated the APO technology allows for sustainable process design by minimizing material use and selecting non-toxic reagents, translating into reductions of the drug development costs.