Author: Christiana Briddell

Sustainability in Organic Chemistry: 20 Years of the ACS GCIPR Grants Program

Join session organizers Isamir Martinez (ACS GCI) and Paul Richardson (Pfizer) in this ORGN session exploring new approaches to chemical synthesis relevant to the pharmaceutical industry that utilize green chemistry. This session highlights academic research funded by the ACS GCI Pharmaceutical Roundtable.

This session has 10 presentations:

2:00 PM Introductory Remarks
2:05 PM HTE platform for developing greener C-H amination chemistries
2:35 PM Increasing sustainability in polymer synthesis: from peptides to nanoparticles
3:05 PM Complex fragment coupling via MHAT / SH2 reactions
3:35 PM Intermission
3:50 PM Biocatalytic and chemoenzymatic strategies for accessing privileged small molecules
4:20 PM Innovations in peptide synthesis fueled by a focus on green chemistry
4:50 PM Sustainable nitrogen atom transfer reactions to access small ring heterocycles
5:20 PM Industry and academic partnerships: new problems and a little funding add up to big advancements
5:50 PM Concluding Remarks

2:00 p.m. – 5:55 pm, PST
Sunday, March 23, 2025
Room 30E (San Diego Convention Center)
Link to program

Sustainability in Organic Chemistry: Special Student and Postdoc Session

The development of new synthetic methodologies and strategies has been the cornerstone upon which sustainable industrial processes are built. The pure research advances arising from academia fuel the world’s industrial innovation while also training the scientific leaders of tomorrow. This special session highlights the research of graduate students and postdoctoral scholars across the broader, global organic chemistry community, which has the potential to impact sustainable industrial chemistry. From abstracts submitted to this session, eight or more students will be selected to:

Give a 20-minute oral presentation
Receive up to $1200 each in travel reimbursement
Be invited to a pre-conference, full-day student workshop
Be invited to the exclusive ACS GCI Industrial Roundtable Poster Reception

Session Organizer: David Leahy, Biohaven

GC&E Conference

Presented at the

This session will be presented at the 29th Annual Green Chemistry & Engineering Conference, which will be held in Pittsburgh, PA, on June 23-26, 2025. Call for abstracts is open January 3–February 14, 2025. For more information, see www.gcande.org.

Practical Considerations for a More Sustainable Medicinal Chemistry DMTA Lifecycle

Covering topics such as in silico tools to filter compound designs to reduce the number of compounds being synthesized; direct to biology type technologies; practical methods to carry out ‘greener chemistry’ for example novel (more efficient/sustainable) methodologies for classical reaction types; new purification methods; alternative reagents to avoid toxic/environmentally damaging reagents; reaction miniaturization efforts for Medicinal Chemistry (beyond hit finding).

Session Organizers: Paul Richardson, Pfizer; Kristy Anderson, Boehringer Ingelheim; Alvaro Enriquez Garcia, Lilly.

GC&E Conference

Presented at the

Twenty Years of Sustainable Continuous Flow Chemistry: Lessons Learned

This symposium plans to unite various practitioners of Flow Chemistry across a broad range of modalities and track the evolution of Flow, highlighting the synergies not only with other technologies but also with the academic community. The latter is showcased by a number of grants awarded in this space, while overlaps exist with the Medicinal Chemistry, Peptides, Oligos, and Analytical Teams, amongst others.

Session Organizers: Paul Richardson, Pfizer; Olivier Dapremont, SK Pharmteco

GC&E Conference

Presented at the

Peptides, Pepteins, and Proteins: Greener Biomolecule Production and Analysis

Sustainability awareness has increased throughout the chemical and biochemical industries. This awareness has resulted in a desire to improve production processes using greener approaches. This session will share technological advances to reduce the environmental impact of biomolecule production and will include sustainability advances in solid-phase peptide synthesis, hybrid approaches to peptide production, recombinant peptide and peptein production, protein production, and analysis methods enabling these advances.

Session Organizers: Matthew Sobansky, Zoetis

GC&E Conference

Presented at the

Data Science Applications in Base Metal Catalysis

Advancements in base metal catalysis over the last decades have provided scientists with a wide range of synthetic tools to build organic small molecules. These new methodologies have broadened the substrate scope and improved our understanding of reaction mechanisms, resulting in more efficient approaches to building small molecules. In addition to new base-metal-catalyzed transformations, the advance in data science and machine learning has enabled scientists to gain insights and predictions of chemical transformation before conducting laboratory experiments. These tools offer advantageous opportunities to promote and enhance sustainability in chemical development. Therefore, the understanding and illustration of green base-metal-catalyzed synthetic methods in combination with AI/ML applications from different perspectives (i.e., academic-level chemists, industrial scientists) may provide important insights in promoting and practicing green chemistry and sustainability. Therefore, it is vital to bring scientists from different backgrounds to the same platform so that they can learn from one another on the topics of sustainability and green chemistry.

Thus, this symposium focuses on bringing synthetic chemists and chemical engineers from various academic and industrial settings to showcase their base-metal catalysis and/or AI/ML work. It will involve scientists from various stages of their careers to provide different perspectives and approaches towards green chemistry. Invited speakers will consist of both chemists and chemical engineers from academia and industry. The symposium will cover a wide range of base metal catalysis and AI/ML topics, including base metal-catalyzed methodologies, mechanistic understanding, AI/ML applications to synthetic chemistry, and computationally assisted ligand designs. These topics will showcase their respective approaches to addressing sustainability problems and the fundamental limitations in green chemistry. The knowledge gained by the audience from the symposium will help inform and educate the current and future workforce with various chemical and technological advancements in accelerating sustainability and green chemistry.

Session Organizers: Jacob Ganley, Bristol Myers Squibb; Kristine Golden, Bristol Myers Squibb

GC&E Conference

Presented at the

Author: Christiana Briddell

Sustainability in Organic Chemistry: 20 Years of the ACS GCIPR Grants Program

Sustainability in Organic Chemistry: Special Student and Postdoc Session

GC&E Conference

Practical Considerations for a More Sustainable Medicinal Chemistry DMTA Lifecycle

GC&E Conference

Twenty Years of Sustainable Continuous Flow Chemistry: Lessons Learned

GC&E Conference

Peptides, Pepteins, and Proteins: Greener Biomolecule Production and Analysis

GC&E Conference

Data Science Applications in Base Metal Catalysis

GC&E Conference

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