2026 CMO Excellence in Green Chemistry Award
The Aralez Bio team is honored for developing a pioneering biocatalysis platform that enables large‑scale, sustainable manufacturing of noncanonical amino acids (ncAAs), critical building blocks in next‑generation therapeutics. Traditional chemical synthesis of ncAAs is often resource‑intensive, inefficient, and environmentally burdensome. Aralez Bio’s technology overcomes long‑standing challenges in biocatalysis, including reaction reversibility, high aqueous volumes, complex downstream processing, and enzyme instability. Their specialized platform supports streamlined, stable, and highly efficient enzymatic transformations.
Within the past year, Aralez Bio expanded its capabilities to include hundreds of additional ncAAs and successfully demonstrated kilogram‑scale production, delivering 20–50 kg batches of key targets. Their biocatalytic processes significantly reduce electricity use, CO₂ emissions, hazardous chemical uses, and overall environmental impact compared with conventional chemical routes. Beyond operational sustainability, Aralez Bio’s ncAAs provide a bio‑based alternative to petroleum‑derived materials, further advancing greener therapeutic development.
Team Members
