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PMI Life Cycle Assessment

The PMI-LCA Tool is a high-level estimator of Process Mass Intensity (PMI) and environmental life cycle information that can be customized to fit a wide variety of linear and convergent processes for synthesis of small molecule active pharmaceutical ingredients (APIs). An ecoinvent dataset is utilized as the source of the life cycle impact assessment (LCIA) data.

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Related Content

Green Chemistry Using Smarter Metrics: A Life Cycle Approach

Chemists and chemical engineers hold immense power to reduce environmental impact through the choices they make, especially when selecting synthetic routes. But how can they be sure they’re making the greener choice?

The ACS GCI Pharmaceutical Roundtable has developed robust metrics to advance decision making in development of greener synthetic processes, not just for the pharmaceutical sector, but in academic research and in other industries as well. Join David Entwistle of Codexis and Benjamin Küehne of Merck, KGaA (Germany) as they discuss the importance of metrics in driving process development and discover how these tools are helping chemists make faster, smarter, and more sustainable decisions. Register now to gain practical insights through real-world case studies and learn how to elevate your process development with powerful sustainability tools like the new Process Mass Intensity (PMI) Life Cycle Assessment (LCA) Tool.

This ACS Webinar is moderated by Adelina Voutchkova-Kostal of the American Chemical Society and co-produced with the ACS GCI Pharmaceutical Roundtable.

Watch the Webinar

Webinar graphic showing excel spreadsheet overlayed with sustainability icons

Process Mass Intensity Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis

Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis. Ivy Kekessie*, Katarzyna Wegner, Isamir Martinez, Michael E. Kopach, Timothy D. White, Janine K. Tom, Martin N. Kenworthy, Fabrice Gallou, John Lopez, Stefan G. Koenig, Philippa R. Payne, Stefan Eissler, Balasubramanian Arumugam, Changfeng Li, Subha Mukherjee, Albert Isidro-Llobet, Olivier Ludemann-Hombourger, Paul Richardson, Jörg Kittelmann, Daniel Sejer Pedersen, and Leendert J. van den Bos. J. Org. Chem. 2024, 89, 7, 4261–4282. https://doi.org/10.1021/acs.joc.3c01494.