Celebrate groundbreaking advancements in green chemistry and engineering in the pharmaceutical industry, featuring the 2024 Peter J. Dunn Award winners. Established in 2016, the Award recognizes exceptional industrial implementations that achieve significant environmental, safety, cost, and efficiency improvements over existing technologies. This year’s honorees, Boehringer Ingelheim and GSK, have set new standards in sustainable manufacturing.
Boehringer Ingelheim’s team created a highly efficient 3-step synthesis for Spiroketone CD 7659, used across multiple projects. Join Yongda Zhang, a Distinguished Research Fellow in Process Research at Boehringer Ingelheim as he discusses how their process improved yield nearly five-fold, reduced solvent usage by 99 percent, and eliminated halogenated solvents. The sustainability impact was significant, with a PMI of 117, an outstanding Relative Process Greenness (RPG) score of 72 percent, and a top-tier innovation Green Aspiration Level (iGAL). Scalable to meet increasing demand, learn how their method will save over 69 million kg of waste at one of the world’s largest pharmaceutical companies. GSK’s team developed a second-generation route for manufacturing the cancer drug maleimidocaproyl monomethyl auristatin F (mcMMAF) which reduces solvent consumption by 16,160 kg per kilogram of product, cuts greenhouse gas emissions by 71 percent, and slashes energy consumption by 76 percent. Join Danny Mancheno, a Research Scientist at GSK as he discusses their innovative approach that also eliminated single-use silica gel chromatographic separations, achieving an impressive 76 percent reduction in Process Mass Intensity (PMI).
Don’t miss this opportunity to learn from industry leaders in the sustainability space as they share insights into these award-winning projects and their contributions to a greener future. This ACS Webinar is moderated by John Tucker of Neurocrine Biosciences and is co-produced by the ACS Green Chemistry Institute Pharmaceutical Roundtable.
