Continuous Flow
The overwhelming majority of bulk active pharmaceutical ingredient manufacturing is accomplished through the use of traditional batch chemical unit operations. Roundtable members have organized around a shared desire to promote the development, implementation, and routine use of continuous flow technologies within the pharmaceutical industry and to quantify the benefits from a green perspective.
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Twenty Years of Sustainable Continuous Flow Chemistry: Lessons Learned
This symposium plans to unite various practitioners of Flow Chemistry across a broad range of modalities and track the evolution of Flow, highlighting the synergies not only with other technologies but also with the academic community. The latter is showcased by a number of grants awarded in this space, while overlaps exist with the Medicinal Chemistry, Peptides, Oligos, and Analytical Teams, amongst others.
Session Organizers: Paul Richardson, Pfizer; Olivier Dapremont, SK Pharmteco
GC&E Conference
Presented at the
This session will be presented at the 29th Annual Green Chemistry & Engineering Conference, which will be held in Pittsburgh, PA, on June 23-26, 2025. Call for abstracts is open January 3–February 14, 2025. For more information, see www.gcande.org.
Overcoming light penetration challenges in photochemical reactions through a micro-LED packed bed reactor
Andrew Teixeira and Patricia Musacchio of Worcester Polytechnic Institute, $80,000 “Overcoming light penetration challenges in photochemical reactions through a micro-LED packed bed reactor”
Realizing the advantages of alternating polarity electrosynthesis at constant potential through controlled mass transport
Marcel Schreier and Shannon Stahl of the University of Wisconsin Madison, $80,000 “Realizing the advantages of alternating polarity electrosynthesis at constant potential through controlled mass transport”
New technology for continuous flow liquid-phase sustainable synthesis of therapeutic peptides
Walter Cabri, Alessandra Tolomelli, and Lucia Ferrazzano, University of Bologna, $80,000 “New technology for continuous flow liquid-phase sustainable synthesis of therapeutic peptides”
Simplified PAT Strategies for Calibration-Free Real-Time Data Gathering and Utilization in Automated Flow Chemistry Platforms
C. Oliver Kappe, University of Graz, Austria, $50,000 “Simplified PAT Strategies for Calibration-Free Real-Time Data Gathering and Utilization in Automated Flow Chemistry Platforms”
Learning to Extrude Chemical Reactions
Duncan Browne, University College of London, $50,000 “Learning to Extrude Chemical Reactions”
Enz-Flow/Continuous Bioprocessing: Towards a green continuous flow synthesis of levomilnacipran
Amanda C. Evans, Ph.D., California State University, $50,000 “Enz-Flow/Continuous Bioprocessing: Towards a green continuous flow synthesis of levomilnacipran”
Tandem catalytic process in flow: synthesis of amides via mild photochemical carbonylation using CO2 as a carbonyl source
Graham Dobereiner, Ph.D., Temple University, $50,000 “Tandem catalytic process in flow: synthesis of amides via mild photochemical carbonylation using CO2 as a carbonyl source”
Process Development of Continuous Flow Oxidative Biotransformations
A. John Blacker, Ph.D., University of Leeds, $50,000 “Process Development of Continuous Flow Oxidative Biotransformations”
Pharmaceutical Roundtable Study Demonstrates the Value of Continuous Manufacturing in the Design of Greener Processes
Pharmaceutical Roundtable Study Demonstrates the Value of Continuous Manufacturing in the Design of Greener Processes Peter Poechlauer, Juan Colberg, Elizabeth Fisher, Michale Jansen, Martin D. Johnson, Stefan G. Koenig, Michael Lawler, Thomas Laporte, Julie Manley, Benjamin Martin, and Ann O’Kearney-McMullan. Org. Process Res. Dev. 2013, 17 (12), 1472-1478. DOI: 10.1021/op400245s