Skip to main content

Bringing Macrolactamization Full Circle: Self-Cleaving Head-to-Tail Macrocyclization of Unprotected Peptides via Mild N-Acyl Urea Activation

Miles H. Aukland, Theresa Dutschei, Oliver D. Engl, Pascal S. Engl, Álvaro Enríquez García, Alejandro Gimenez Molina, Vanessa Harawa, Christopher B. Kelly, Alexandre Leclair, Johnny W. Lee, Zhen Lei, Wei Li, Matthew Osborne, Kedwin Rosa Pagan, Jan Pawlas, Paul F. Richardson, Amarjit Singh, William J. Smith, Alan Steven, Balaram S. Takale; Green Chemistry Articles of Interest to the Pharmaceutical Industry. Org. Process Res. Dev. 17 April 2026; 30 (4): 807–816. https://doi.org/10.1021/acs.oprd.5c00432