2024 CMO Excellence in Green Chemistry Award
The PharmaBlock team was selected based on their innovative work on “Sustainable Manufacturing Process for Commercial and Developmental Stage Intermediates through Two Consecutive Flow Reactions using Micro-Packed Bed Technology.” Team members are Feng Zhang, Guangchao Ma, Dafen Wen, Yang Zhu, and Yuanxian Wang, all based in Nanjing, China. Their project demonstrated the use of micro-packed bed technology to produce tert-Butyl 3-oxoazetidine-1-carboxylate and tert-Butyl 3-aminoazetidine-1-carboxylate through oxidation reactions and reductive amination reactions at scale, resulting in improvements to safety, equipment volume efficiency, process mass intensity (PMI), greenness, and cost efficiency.
More about the Award
The CMO Excellence in Green Chemistry Award seeks to recognize outstanding efforts by CMO companies in pharmaceutical green chemistry in support of pharmaceutical research, development, and manufacturing that demonstrate compelling environmental, safety, and/or efficiency improvements. The award recognizes greener advances in synthetic route development for starting materials, intermediates, or active pharmaceutical ingredients (APIs), including reaction conditions and chemical or manufacturing technologies.
This annual award is presented at the Green Chemistry & Engineering Conference where a member of the winning team is invited to share their team’s innovations.
Pictured: Wang Yuanxian, Director of R&D at PharmaBlock, accepts the 2024 CMO Excellence in Green Chemistry Award from Isamir Martinez (ACSGCI) and ACS GCIPR 2024 Co-Chair, Dan Bailey of Takeda.
