Walter Cabri, Alessandra Tolomelli, and Lucia Ferrazzano, University of Bologna, $80,000
“New technology for continuous flow liquid-phase sustainable synthesis of therapeutic peptides”

Hans Renata of Rice University, $80,000
“Biocatalytic Synthesis of Phosphorothioate-Containing Nucleosides”

Marcel Schreier and Shannon Stahl of the University of Wisconsin Madison, $80,000
“Realizing the advantages of alternating polarity electrosynthesis at constant potential through controlled mass transport”

Andrew Teixeira and Patricia Musacchio of Worcester Polytechnic Institute, $80,000
“Overcoming light penetration challenges in photochemical reactions through a micro-LED packed bed reactor”

Jeffrey Lipshultz, Stony Brook University, $40,000
“Aminomutase-Inspired Green Radical Amination”

Marvin Parasram, New York University, $40,000
“Dihydroxylation of Propellanes via Tandem Cycloaddition/Hydrogenation of Photoexcited Nitroarenes”

Bruce Arndtsen, McGill University, $40,000
“A Versatile Approach to Carboxylic Acid Derivatives with Earth Abundant Catalysts and Visible Light”

Neil Dixon, Manchester Institute of Biotechnology, $40,000
“Sustainable Solvent Production”

Yang Hai, University of California Santa Barbara, $50,000
“Application of a PLP-dependent Mannich cyclase for biocatalytic synthesis of heterocyclic quaternary α-amino acids”

C. Oliver Kappe, University of Graz, Austria, $50,000
“Simplified PAT Strategies for Calibration-Free Real-Time Data Gathering and Utilization in Automated Flow Chemistry Platforms”

Christopher Sandford, Dartmouth College, $50,000
“Bifunctional Organocatalysts for Sustainable Peptide Bond Formation”

Nicholas Snow, Seton Hall University, $50,000
“‘Greening’ Pharmaceutical Analysis Using Gas Chromatography”

Jack Norton and Aaron Moment, Columbia University, $50,000
“Selective reduction of aromatic rings in advanced scaffolds in flow reactors with non-noble metal catalysis under mild conditions”

Masad J. Damha, McGill University, $50,000
“Oligonucleotide synthesis by resonant acoustic mixing (RAM)”

Jesús Fernández Lucas, Universidad Europea de Madrid, Spain, $25,000
“Enzymatic synthesis of C-nucleosides”

Yu Zhao, National University of Singapore, $25,000
“Electrocatalytic Functionalization of Commodity Alcohols to Produce Valuable Amines and Amides”

Duncan Browne, University College of London, $50,000
“Learning to Extrude Chemical Reactions”

Malgorzata Chwatko, University of Kentucky, $50,000
“Improvement of Peptide Yield and Solvent Reuse via Membrane Enhanced Peptides Synthesis”

Hans Renata, Scripps Research, $50,000
“Biocatalytic Synthesis of Challenging Noncanonical Amino Acids”

Jennifer Schomaker, University of Wisconsin-Madison, $50,000
“Tunable Catalytic C(sp3)-H Functionalization of Heterocyclic Scaffolds”

Qiu Wang, Duke University, $25,000
“Copper-Catalyzed Carbon-Carbon Coupling of Alcohols and Alkenes”

Han Sen Soo, Nanyang Technological University, Singapore, $25,000
“Photocatalytic Carbon-Carbon Bond Activation and Functionalization to Access Unnatural α-Amino Acids”

Mélanie Hall, University of Graz, Austria, $25,000
“Enzymatic nitration strategies for the biocatalytic synthesis of nitrogen containing molecules”

Florian Hollfelder, University of Cambridge, $25,000
“Exploring fitness landscapes of enzymes for chiral synthesis”

Tristan Lambert & Phillip Milner, Cornell University, $50,000
“Bioinspired Metal-Organic Frameworks as Heterogeneous Catalysts for Peptide Synthesis”

Kamalesh K. Sirkar, New Jersey Institute of Technology, $50,000
“Develop membranes for pressure-driven separation of solutes and solvents in the 50-600 Da range from API synthesis mixtures”

Pasi Virta, University of Turku, $50,000
“Improved synthesis of nucleotide blockmers using a precipitative soluble”

Daniel J. Weix, University of Wisconsin-Madison, $50,000
“Metal-Mediated Electrochemistry: A new frontier for surfactants”

Martin Andersson, Technical University of Denmark (DTU), $25,000
“Developing New Surfactants for Easy Separation”

Soumitra Athavale & Frances H. Arnold, California Institute of Technology, $25,000
“Biocatalytic C-H bond Functionalization for the Synthesis of Enantioenriched Amines and Amides”

Matthew A. Hostetler, Marshall University, $25,000
“Cups: An Atom efficient and low-waste producing method of inverse solid-phase peptide synthesis”

Tehshik P. Yoon, University of Wisconsin-Madison, $25,000
“Oxidative C–N Cross-Coupling Enabled by Iron Photochemistry”

Ryan Shenvi, Scripps Research, $50,000
“C–N Attached-Ring Synthesis by Markovnikov Hydroamination”

Susan Olesik, The Ohio State University, $46,996
“A Study of the Environmental Impact of Analytical and Preparative Scale Supercritical Fluid Chromatographic Processes”

Fernando Albericio and Beatriz G. de la Torre, University of KwaZulu-Natal, $25,000
“Baroc, a Green α-Amino Protecting Group for Solid-Phase Peptide Synthesis”

Mark Mason, The University of Toledo, $25,000
“Iron-Catalyzed Cross-Coupling of Heterocycles”

Aaron Vannucci, University of South Carolina, $25,000
“A New Approach to Catalyst Immobilization Research: Designing Molecular Catalysts for Heterogeneous Catalysis”

Arnaud Voituriez, Institut de Chimie des Substances Naturelles, $25,000
“Towards an Electro-Catalytic Wittig Reaction”